Paulo8k's Weblog

Obesity drug has little effect on heart in teens (reuters)

paulo8k — Sun, 09 Mar 2008 09:45:56 +0000

Reuters – When the weight-loss drug
sibutramine, marketed under the brand names Meridia or
Reductil, is used to treat obesity in adolescents, it is
associated with small decreases in blood pressure and pulse
rate, according to a new study. (Source: Yahoo! News: Health News)

6th circuit affirms summary judgment for meridia mdl claims

paulo8k — Sun, 09 Mar 2008 09:45:55 +0000

CINCINNATI – The Sixth Circuit U.S. Court of Appeals on May 11 affirmed summary judgment for product liability claims against Abbott Laboratories in the Meridia diet drug multidistrict litigation (Meridia Products Liability Litigation, Steering Committee, et al. v. Abbott Laboratories, et al., No. 04-4175, 6th Cir.).
Full story on lexis.com (Source: LexisNexis® Mealey’s™ Fen-Phen/Redux Legal News)

Meridia helps obese teenagers lose weight

paulo8k — Fri, 07 Mar 2008 14:04:45 +0000

Meridia (sibutramine), combined with behavioural therapy, has been shown to be effective in helping obese teenagers lose weight, according to a study carried out by Dr. R Berkowitz and team at Children Hospital of Philadelphia. The researchers found the treatment is effective for obese 12-year-olds as well. [click link for full article] (Source: Health News from Medical News Today)

Newsdesk: new clues to how major weight-loss drugs work

paulo8k — Fri, 07 Mar 2008 14:04:44 +0000

Author: NewsEditor
Subject: New Clues To How Major Weight-loss Drugs Work
Posted: Fri 21 Jul 2006 6:05 am (GMT 1)

Some of the most important weight-loss drugs work by enhancing the effect of the brain chemical serotonin. These include sibutramine (trade name Meridia) and fenfluramine, which was recalled after the combination with dexfenfluramine, called…view forum post_________________News Editor, CounsellingResource.com

Also see our Daily Mental Health News Page (Source: CounsellingResource.com News and Features)

New insights into how major weight-loss drugs work

paulo8k — Thu, 06 Mar 2008 07:07:55 +0000

Some of the most important weight-loss drugs work by enhancing the effect of the brain chemical serotonin. These include sibutramine (trade name Meridia) and fenfluramine, which was recalled after the combination with dexfenfluramine, called fen-phen, was linked to potentially fatal heart valve abnormalities.However, little has been known about the molecular mechanism by which serotonin suppresses appetite. [click link for full article] (Source: Obesity / Weight Loss / Fitness News From Medical News Today)

Diet drug may be of little benefit in obese teens (reuters)

paulo8k — Thu, 06 Mar 2008 07:07:54 +0000

Reuters – Obese adolescents who are put
on a low-calorie diet and exercise program do not seem to
derive any additional benefit from taking the diet drug
sibutramine, sold in the United States under the trade name
Meridia, according to a Dutch study. (Source: Yahoo! News: Health News)

Obesity drug has little effect on heart in teens (reuters)

paulo8k — Mon, 03 Mar 2008 09:05:03 +0000

University of london

paulo8k — Mon, 03 Mar 2008 09:05:02 +0000

Maplethorpe Postdoctoral Fellowships in Pharmacy

Amount: �10K – �50K
Closing Date : 01 March 2008 (Source: RDFunding RSS feed)

Boots to help smokers kick habit

paulo8k — Sat, 01 Mar 2008 06:05:49 +0000

Boots Pharmacy, the UK's leading health and beauty store, plans to has unveiled a campaign in the GCC to help customers quit smoking. Under the 'Ask Your Boots Pharmacists" campaign, Boots pharmacists will conduct free one-to-one consultations, as well as provide expert advice in an attempt to help smokers in the region give up smoking for good. (Source: Healthcare)

Natural products as leads to anticancer drugs

paulo8k — Sat, 01 Mar 2008 06:05:48 +0000

Abstract Throughout history, natural products have afforded a rich source of compounds that have found many applications in the fields
of medicine, pharmacy and biology. Within the sphere of cancer, a number of important new commercialised drugs have been obtained
from natural sources, by structural modification of natural compounds, or by the synthesis of new compounds, designed following
a natural compound as model. The search for improved cytotoxic agents continues to be an important line in the discovery of
modern anticancer drugs. The huge structural diversity of natural compounds and their bioactivity potential have meant that
several products isolated from plants, marine flora and microorganisms can serve as ?lead? compounds for improvement of their
therapeutic potential by molecular modification. Additionally, semisynthesis processes of new compounds, obtained by molecular
modification of the functional groups of lead compounds, are able to generate structural analogues with greater pharmacological
activity and with fewer side effects. These processes, complemented with high-throughput screening protocols, combinatorial
chemistry, computational chemistry and bioinformatics are able to afford compounds that are far more efficient than those
currently used in clinical practice. Combinatorial biosynthesis is also applied for the modification of natural microbial
products. Likewise, advances in genomics and the advent of biotechnology have improved both the discovery and production of
new natural compounds.

Content Type Journal ArticleCategory Educational SeriesDOI 10.1007/s12094-007-0138-9Authors
M. Gordaliza, Universidad de Salamanca Departamento de Qu�mica Farmac�utica Facultad de Farmacia Campus Miguel de Unamuno 37007 Salamanca Spain

Journal Clinical and Translational OncologyOnline ISSN 1699-3055Print ISSN 1699-048X

Journal Volume Volume 9

Journal Issue Volume 9, Number 12 / December, 2007 (Source: Clinical and Translational Oncology)